) But, if I CAN come off the Lexapro and still be okay, that would be nice. I am suffering from SEVERE vertigo and feel that the Lexapro, while perhaps not causing that, certainly doesn't help. It might be worth it to ask if you can up the wellbutrin to 300mg and ask your doc and/or pharmacist if all three can be taken together. Also remember that most anti-depressants can take 6-8 weeks to start working, so it might be that long for the lexapro to be effective. Zyrtec (cetirizine) and Vyvanse (lisdexamfetamine) have no known major drug to drug interactions, and can be taken safely together. However this combination may cause a increased sedating effect. I take the Lexapro in the evening, because in the past (when I took Strattera, before I switched to Vyvanse) the Lexapro made me feel a bit dopey and slow if I took it in the morning. Granted, this is only one data point/anecdote. Summary. Drug interactions are reported among people who take Vyvanse and Lexapro together. This study is created by eHealthMe based on reports of 460 people who take Vyvanse and Lexapro from FDA, and is updated regularly. Not likely. If you are asking if the combination of vyvanse and Lexapro (escitalopram) would be more likely than Lexapro (escitalopram) alone to cause serotonin syndrome, i would say 'no': vyvanse's effect doesn't involve serotonin. I've never taken the two together, but I can say that Lexapro made me sleep about 14 hours a day on average while on it. And other than that it didn't do much for anxiety or depression for me. There is a moderate interaction between Lexapro and Vyvanse. You may want to consider another combination. You may want to consider another combination. Always consult your doctor before taking these medications together. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Krauser on vyvanse and lexapro: Per Drugs.Com Citalopram may increase the effects of lisdexamfetamine, and side effects such as jitteriness, nervousness, anxiety, restlessness, and racing thoughts Risk for serotonin syndrome may increase.